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  • First independent government formed among American colonies, March 1776
  • First British fort taken by the Americans under Gen Francis Marion in 1781 (Fort Watson, located in Clarendon County)
  • First state to secede from the Union, December 20, 1860
  • First shot fired in Civil War on Fort Sumter in Charleston Harbor, April 12, 1861
  • First municipal college - College of Charleston, opened April 1, 1838
  • First free library established - Charleston, 1698
  • First public museum - Charleston Museum, organized January 12, 1773
  • First building to be used solely as a theater - Dock Street Theatre in Charleston, constructed in 1736
  • First opera performed in America - Charleston, February 18, 1735
  • First female newspaper publisher in the US. - Elizabeth Timothy, of Charleston. She took over the South Carolina Gazette after her husband died in December 1738.
  • First fireproof building built - Charleston, 1822
  • First ship built in America to cross the Atlantic Ocean - Port Royal, 1562
  • First steam locomotive built in the United States to be used for regular railroad service - "Best Friend of Charleston", 1830
  • First cotton exported to England, 1764
  • First tea planted - Middleton Barony, 1802. First commerical tea farm - Summerville, 1890
  • First indigo planted, 1671
  • First cotton mill built - James Island, 1789
  • First slave insurrection - Stono area near Charleston, 1739
  • First Black Baptist Church established - Silver Bluff, 1773
  • First Medal of Honor awarded to a Black recipient- W. H.Carney (Army), July 18, 1863
  • First Black Associate Justice of a state supreme court - J. J. Wright, February 2, 1870
  • First mutual fire insurance company - Friendly Society for the Mutual Insurance of Houses Against Fire, 1735
  • First business publication - South Carolina Price Current in Charleston, 1774
  • First textile school established in a college - Clemson, 1899
  • First U.S. Senator elected by a write-in vote - Strom Thurmond, November 2, 1954
  • First woman lawyer in South Carolina - Miss J. M. Perry of Greenville was admitted to practice on May 4, 1918.

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